A Review on Plant Derived Efflux Pump Inhibitors Targeting nor An Efflux Pump in Staphylococcus Aureus
نویسندگان
چکیده
منابع مشابه
QSAR Studies on Bacterial Efflux Pump Inhibitors
Antimicrobial drug resistance occurs when bacteria undergo certain modifications to eliminate the effectiveness of drugs, chemicals, or other agents designed to cure infections. To date, the burden of resistance has remained one of the major clinical concerns as it renders prolonged and complicated treatments, thereby increasing the medical costs with lengthier hospital stays. Of complex causes...
متن کاملEffects of synthesized iron oxide nanoparticles from Ziziphora clinopodioides on expression of the efflux pump genes of Staphylococcus aureus
Introduction: One of the important factors causing nosocomial infections is drug-resistant Staphylococcus aureus strain, so correspondingly, having norA efflux pump is one of the bacterial's ability to generate drug resistance. Iron has been used as a nanoparticle with antimicrobial activity against bacteria. The aim of this study was to investigate the effect of iron oxide nanoparticles synthe...
متن کاملBacterial efflux pump inhibitors from natural sources.
The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the discovery of new antibacterials and resistance-modifying agents. Since the initial discovery of bacterial efflux pumps in the 1980s, many have been characterized in community- and hospital-acquired Gram-positive and Gram-negative pathogens, such as Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia c...
متن کاملHomology modeling, molecular dynamics, and virtual screening of NorA efflux pump inhibitors of Staphylococcus aureus
Emerging drug resistance in clinical isolates of Staphylococcus aureus might be implicated to the overexpression of NorA efflux pump which is capable of extruding numerous structurally diverse compounds. However, NorA efflux pump is considered as a potential drug target for the development of efflux pump inhibitors. In the present study, NorA model was constructed based on the crystal structure...
متن کاملInvestigating The Regulation Of A Fatty Acid Efflux Pump In Methicillin Resistant Staphylococcus Aureus
............................................................................................................................. ii Co-Authorship Statement ............................................................................................... iii Acknowledgments ............................................................................................................ iv Table of
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ژورنال
عنوان ژورنال: International Journal of Scientific Research in Science and Technology
سال: 2020
ISSN: 2395-602X,2395-6011
DOI: 10.32628/ijsrst20754